Cinnamic acids and derivatives
Cayman Chemical m-CoumarIc AcId 5g
An active metabolite of polyphenols; inhibits cumene hydroperoxide-induced oxidation of DNA (IC50 = 54.7 µM); induces neurite outgrowth of fetal rat hippocampal neurons at 10 µM; induces apoptosis and cell cycle arrest at the G0/G1 phase in HeLa cells at 5 and 10 mM, respectively; increases locomotor activity in mice at 3 mmol/kg
Apexbio Technology LLC Sodium ferulic 24276-84-4 100mg
Sodium ferulic (CAS 24276-84-4) is a small molecule inhibitor targeting fibroblast growth factor receptors specifically FGFR1 and FGFR2 It demonstrates inhibitory activity with IC50 values of 3 78 M for FGFR1 and 12 5 M for FGFR2 At the cellular level sodium ferulic suppresses intracellular signaling pathways involved in cell proliferation This compound is utilized in biomedical research to investigate signaling mechanisms and to assess therapeutic potential in disease models such as cancer
Cayman Chemical p-CoumarIc AcId 10g
A hydroxy derivative of cinnamic acid that can be found in a variety of edible plants that is reported to have antioxidant, anti-inflammatory, and antimicrobial activity
Medchemexpress LLC Ferulic acid methyl ester (methyl ferulate) | 2309-07-1 | MFCD00017208 | 100.0% | 208.21 g·mol⁻¹ | C11H12O4 | 5 G
Ferulic acid methyl ester is the methyl ester derivative of ferulic acid supplied for research use. It is reported to be cell membrane- and brain-permeable, with antioxidant and anti-inflammatory activity, and has been used to study MAPK signaling and COX-2 expression. The compound is provided at high purity for biochemical and cellular research applications.
- Methyl ester derivative of ferulic acid
- Antioxidant and anti-inflammatory activity
- Cell membrane and brain permeable
- Modulates MAPK signaling and COX-2 expression
- High purity suitable for research applications
Cayman Chemical FerulIc AcId methyl ester 5g
A lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes; at 10-25 UG/ml, inhibits the release of pro-inflammatory cytokines, blocks the expression of COX-2, and reduces NO generation from LPS-stimulated macrophages
eMolecules Trans-4-Hydroxycinnamic Acid | 501-98-4 | MFCD00004399 | 25g
Ambeed | Trans-4-Hydroxycinnamic Acid | 25g | 552634112 | A192873 | | 501-98-4 | MFCD00004399 | 164.160 | C9H8O3
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Medchemexpress LLC 2-chlorocinnamic acid | 3752-25-8 | MFCD00004372 | 99.8% | 182.60 g/mol | C9H7ClO2 | 10 G
2-Chlorocinnamic acid (CAS 3752-25-8) is the 2-chloro analogue of cinnamic acid, present predominantly as the trans (E) isomer. It is supplied as a research-grade chemical for use as a building block, synthetic intermediate, and analytical reference in organic and medicinal chemistry; molecular formula C9H7ClO2, molar mass 182.60 g/mol.
- High purity (≈99.8%).
- Predominantly trans (E) isomer.
- Crystalline solid; easy to handle and store.
- Used as a synthetic building block and intermediate.
- Suitable as an analytical reference standard and for method development.
- Available as a solid and as a 10 mM solution in DMSO.
- Documentation available: datasheet, certificate of analysis, and safety data sheet.
Selleck Chemical LLC p-Coumaric acid ethyl ester
p-Coumaric acid ethyl ester is the ethyl ester of p-Coumaric acid which is a plant metabolite which exhibits antioxidant and anti-inflammatory properties
eMolecules 5-Bromo-2-methoxycinnamic acid | 40803-53-0 | MFCD00017596 | 1g
Oakwood Chemical | 5-Bromo-2-methoxycinnamic acid | 1g | 537672218 | 011098 | | 40803-53-0 | MFCD00017596 | 257.083 | C10H9BrO3
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 1 ML
Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 1 ML
Medchemexpress LLC MRL-494 hydrochloride | 2699937-04-5 | 98.6% | 50 MG
MRL-494 hydrochloride is an antibacterial agent that functions as an inhibitor of β-barrel assembly machine A (BamA), making it impervious to efflux and the outer membrane permeability barrier. It is effective against both Gram-positive and Gram-negative bacteria, with an MIC of 12.5 μM for *Staphylococcus aureus* COL and 25 μM for *E. coli* JCM158.
- Inhibits β-barrel assembly machine A (BamA)
- Impervious to efflux and the outer membrane permeability barrier
- Exhibits strong activity against both Gram-positive and Gram-negative bacteria
- Lethally disrupts the cytoplasmic membrane
- Inhibits outer membrane proteins (OMPs) biogenesis
Cayman Chemical Plnt TurmerIc CurcumIn 10g
A yellow pigment with diverse biological activities; inhibits NO production (IC50 = 6 μM) and reduces iNOS activity in LPS-stimulated RAW 264.7 cells; inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells; decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis; prevents ovalbumin-induced accumulation of 3-NT in mouse heart; reduces TPA-induced tumor formation in mouse skin (1-10 μmol); reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-NQO in rats
Medchemexpress LLC Arn 077 enantiomer | 1439366-88-7 | 99.7% | 1 MG
Arn 077 enantiomer is the less active enantiomer of ARN 077 and functions as an inhibitor of N-acylethanolamine acid amidase (NAAA); reported IC50 for rat NAAA is 3.53 μM. Supplied as a solid for research applications.
- Less active enantiomer with reported IC50 = 3.53 μM for rat NAAA.
- Chemical formula C16H21NO4; molecular weight 291.34 g/mol.
- White to off-white solid; powder storage at -20°C for long-term stability.
- High DMSO solubility (100 mg/mL); vehicle formulations reported for in vivo use at ≥ 2.5 mg/mL.
- For research use only; handle according to appropriate safety procedures.
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.58% | 339.39 | 100 MG
Curcumin 5-8 is a potent, orally active curcumin analog. It inhibits lipid droplet formation, increases autophagy, and inhibits apoptosis. It also improves insulin resistance and insulin sensitivity, and has been shown to ameliorate nonalcoholic fatty liver disease in mice.
- Decreases PA-induced SREBP1 expression and increases Bcl2/BAX expression in AML12 cells.
- Exhibits cytotoxic activity against B16, HUVEC, SiHa, U-87MG ATCC, and Vero cell lines.
- Ameliorates insulin resistance and hepatic steatosis in HFD-induced obese mice.
eMolecules 4'-(4-Fluorobenzyloxy)acetophenone | 72293-96-0 | MFCD00173651 | 25g
Oakwood Chemical | 4'-(4-Fluorobenzyloxy)acetophenone | 25g | 537669236 | 008324 | | 72293-96-0 | MFCD00173651 | 244.265 | C15H13FO2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool